Anti-CD44 antibody {PE-Cy7} (STJ11109131)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationPE-Cy7
IsotypeIgG
ImmunogenRecombinant protein (or fragment).This information is considered to be commercially sensitive.
General Information
| Short Description | Rabbit monoclonal CD44 antibody for use in FC in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Isotype | IgG |
| Conjugation | PE-Cy7 |
| Purification | Affinity purification |
| Dilution Range | FC, 5 Mu l per 10^6 cells in 100 Mu l volume |
| Formulation | PBS with 0.09% Sodium azide, 0.2% BSA, pH7.3. |
| Storage Instruction | Store at 4°C for up to 1 year from the date of receipt. Do not freeze. |
Target Information
| Gene Symbol | Cd44 |
| Gene ID | 12505 |
| Uniprot ID | CD44_MOUSE |
| Immunogen | Recombinant protein (or fragment).This information is considered to be commercially sensitive. |
Additional Info
| Tissue Specificity | Expressed in the intestinal epithelium. |
| Post Translational Modifications | N-glycosylated. O-glycosylated.contains chondroitin sulfate glycans which can be more or less sulfated. Phosphorylated.activation of PKC results in the dephosphorylation of Ser-742 (constitutive phosphorylation site), and the phosphorylation of Ser-708. |
| Function | Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases. Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion. |
| Protein Name | Cd44 AntigenExtracellular Matrix Receptor IiiEcmr-IiiGp90 Lymphocyte Homing/Adhesion ReceptorHutch-IHermes AntigenHyaluronate ReceptorLymphocyte Antigen 24Ly-24Phagocytic Glycoprotein 1Pgp-1Phagocytic Glycoprotein IPgp-ICd Antigen Cd44 |
| Database Links | Reactome: R-MMU-1474228Reactome: -MMU-202733Reactome: -MMU-216083Reactome: -MMU-2160916Reactome: -MMU-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell ProjectionMicrovillusSecretedColocalizes With Actin In Membrane Protrusionfs At Wounding EdgesCo-Localizes With RdxEzr And Msn In Microvilli |
| Alternative Antibody Names | Anti-Cd44 Antigen antibodyAnti-Extracellular Matrix Receptor Iii antibodyAnti-Ecmr-Iii antibodyAnti-Gp90 Lymphocyte Homing/Adhesion Receptor antibodyAnti-Hutch-I antibodyAnti-Hermes Antigen antibodyAnti-Hyaluronate Receptor antibodyAnti-Lymphocyte Antigen 24 antibodyAnti-Ly-24 antibodyAnti-Phagocytic Glycoprotein 1 antibodyAnti-Pgp-1 antibodyAnti-Phagocytic Glycoprotein I antibodyAnti-Pgp-I antibodyAnti-Cd Antigen Cd44 antibodyAnti-Cd44 antibodyAnti-Ly-24 antibody |
Information sourced from Uniprot.org