Anti-CD41/ITGA2B antibody [HIP8] {AF488} (STJA0000455)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationAF488
IsotypeIgG1k
General Information
| Short Description | Mouse monoclonal anti-Integrin alpha-IIb for use in FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Mouse |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | HIP8 |
| Isotype | IgG1k |
| Conjugation | AF488 |
| Concentration | 5 Mu L/Test |
| Formulation | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Storage Instruction | Store between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
Target Information
| Gene Symbol | ITGA2B |
| Gene ID | 3674 |
| Uniprot ID | ITA2B_HUMAN |
Additional Info
| Tissue Specificity | Isoform 1 and isoform 2 are expressed in platelets and megakaryocytes, but not in reticulocytes. Not detected in Jurkat, nor in U937 cell lines. Isoform 3 is expressed in prostate adenocarcinoma, as well as in several erythroleukemia, prostate adenocarcinoma and melanoma cell lines, including PC-3, DU-145, HEL, WM983A, WM983B and WM35. Not detected in platelets, nor in normal prostate (at protein level). |
| Post Translational Modifications | Integrin alpha-IIb heavy chain: Cleaved by ELANE.the cleavage promotes activation of platelet fibrinogen receptor integrin alpha-IIb/beta-3. |
| Function | Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. |
| Protein Name | Integrin Alpha-IibGpalpha IibGpiibPlatelet Membrane Glycoprotein IibCd Antigen Cd41 Cleaved Into - Integrin Alpha-Iib Heavy Chain - Integrin Alpha-Iib Light Chain - Form 1 - Integrin Alpha-Iib Light Chain - Form 2 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-216083Reactome: R-HSA-3000178Reactome: R-HSA-354192Reactome: R-HSA-354194Reactome: R-HSA-372708Reactome: R-HSA-445144Reactome: R-HSA-5674135Reactome: R-HSA-6802946Reactome: R-HSA-6802948Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-8936459Reactome: R-HSA-9649948Reactome: R-HSA-9656223 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Integrin Alpha-Iib antibodyAnti-Gpalpha Iib antibodyAnti-Gpiib antibodyAnti-Platelet Membrane Glycoprotein Iib antibodyAnti-Cd Antigen Cd41 Cleaved Into - Integrin Alpha-Iib Heavy Chain - Integrin Alpha-Iib Light Chain - Form 1 - Integrin Alpha-Iib Light Chain - Form 2 antibodyAnti-ITGA2B antibodyAnti-GP2B antibodyAnti-ITGAB antibody |
Information sourced from Uniprot.org