![Anti-CD4 antibody [Edu-2] {APC} (STJA0018251)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/186967/412543/STJA0018251_1__21190.1747839591.png?c=1 "Anti-CD4 antibody [Edu-2] {APC} (STJA0018251)")
![Anti-CD4 antibody [Edu-2] {APC} (STJA0018251)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/186967/412543/STJA0018251_1__21190.1747839591.png?c=1 "Anti-CD4 antibody [Edu-2] {APC} (STJA0018251)")
Anti-CD4 antibody [Edu-2] {APC} (STJA0018251)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationAPC
IsotypeIgG2a
General Information
| Short Description | Mouse monoclonal anti-T-Cell Surface Glycoprotein Cd4 for use in FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Mouse |
| Reactivity | Human |
| Note | FOR RESEARCH USE ONLY (RUO). |
Product Properties
| Clonality | Monoclonal |
| Clone ID | Edu-2 |
| Isotype | IgG2a |
| Conjugation | APC |
| Purification | Protein A purification |
| Dilution Range | Please carry out application specific titration to determine the most appropriate dilution ratio. |
| Formulation | PBS with 0.2% BSA, and 0.09% Sodium Azide |
| Storage Instruction | Shipped on gel ice packs. Store at 2-8C on arrival. |
Target Information
| Gene Symbol | CD4 |
| Gene ID | 920 |
| Uniprot ID | CD4_HUMAN |
Additional Info
| Post Translational Modifications | Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts. Phosphorylated by PKC.phosphorylation at Ser-433 plays an important role for CD4 internalization. |
| Function | Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages. (Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1). Down-regulated by HIV-1 Vpu. Acts as a receptor for Human Herpes virus 7/HHV-7. |
| Protein Name | T-Cell Surface Glycoprotein Cd4T-Cell Surface Antigen T4/Leu-3Cd Antigen Cd4 |
| Database Links | Reactome: R-HSA-1462054Reactome: R-HSA-167590Reactome: R-HSA-173107Reactome: R-HSA-180534Reactome: R-HSA-202424Reactome: R-HSA-202427Reactome: R-HSA-202430Reactome: R-HSA-202433Reactome: R-HSA-389948Reactome: R-HSA-449836Reactome: R-HSA-8856825Reactome: R-HSA-8856828 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinLocalizes To Lipid RaftsRemoved From Plasma Membrane By Hiv-1 Nef Protein That Increases Clathrin-Dependent Endocytosis Of This Antigen To Target It To Lysosomal DegradationCell Surface Expression Is Also Down-Modulated By Hiv-1 Envelope Polyprotein Gp160 That Interacts WithAnd Sequesters Cd4 In The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-T-Cell Surface Glycoprotein Cd4 antibodyAnti-T-Cell Surface Antigen T4/Leu-3 antibodyAnti-Cd Antigen Cd4 antibodyAnti-CD4 antibody |
Information sourced from Uniprot.org