Anti-CD37/TSPAN26 antibody [Fs0323] {PE} (STJA0031940)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationPE
IsotypeIgG1k
General Information
| Short Description | Mouse monoclonal anti-CD37/TSPAN26 for use in ELISA, FCM and Neut in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/FCM/Neut |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | Fs0323 |
| Isotype | IgG1k |
| Conjugation | PE |
| Purification | Affinity chromatography |
| Formulation | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. |
| Storage Instruction | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| Endotoxin | Please contact us for this information. |
Target Information
| Gene Symbol | CD37 |
| Gene ID | 951 |
| Uniprot ID | CD37_HUMAN |
Additional Info
| Post Translational Modifications | Tyrosine phosphorylated.leading to activation of downstream signaling pathways. |
| Function | Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Upon ligand binding, two signaling pathways are activated, one acting through phosphorylation by LYN leading to cell death or a survival pathway with activation of GSK3B. Plays an essential role essential for clustering of integrin ITGA4/ITGB1 and promotes its mobility in the plasma membrane of B-cells. In turn, participates in ITGA4/ITGB1 integrin-mediated antiapoptotic signaling through AKT. Also plays a role in the migration of dendritic cells and neutrophils to draining lymph nodes, as well as in their integrin-mediated adhesion. Negatively regulates IL-6 responses through direct interaction with SOCS3 thereby preventing constitutive IL-6 signaling. Alternatively, inhibition of IL-6 signaling can also occur via interaction and stabilization of DECTIN1/CLEC7A at the cell membrane to inhibit its ability to promote the production of IL-6. |
| Protein Name | Leukocyte Antigen Cd37Tetraspanin-26Tspan-26Cd Antigen Cd37 |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Leukocyte Antigen Cd37 antibodyAnti-Tetraspanin-26 antibodyAnti-Tspan-26 antibodyAnti-Cd Antigen Cd37 antibodyAnti-CD37 antibodyAnti-TSPAN26 antibody |
Information sourced from Uniprot.org