Anti-CD369/CLEC7A antibody [15E2#] (STJA0027281)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
General Information
| Short Description | Mouse monoclonal C-Type Lectin Domain Family 7 Member A antibody for use in FC in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 15E2# |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Concentration | 1 mg/ml |
| Purification | Protein A/G purified from cell culture supernatant. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | CLEC7A |
| Gene ID | 64581 |
| Uniprot ID | CLC7A_HUMAN |
Additional Info
| Post Translational Modifications | Phosphorylated on tyrosine residues in response to beta-glucan binding. |
| Function | Lectin that functions as a pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans. |
| Protein Name | C-Type Lectin Domain Family 7 Member ABeta-Glucan ReceptorC-Type Lectin Superfamily Member 12Dendritic Cell-Associated C-Type Lectin 1Dc-Associated C-Type Lectin 1Dectin-1Cd Antigen Cd369 |
| Database Links | Reactome: R-HSA-5607764 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinIsoform 5: CytoplasmIsoform 6: CytoplasmIsoform 7: Cytoplasm |
| Alternative Antibody Names | Anti-C-Type Lectin Domain Family 7 Member A antibodyAnti-Beta-Glucan Receptor antibodyAnti-C-Type Lectin Superfamily Member 12 antibodyAnti-Dendritic Cell-Associated C-Type Lectin 1 antibodyAnti-Dc-Associated C-Type Lectin 1 antibodyAnti-Dectin-1 antibodyAnti-Cd Antigen Cd369 antibodyAnti-CLEC7A antibodyAnti-BGR antibodyAnti-CLECSF12 antibodyAnti-DECTIN1 antibodyAnti-UNQ539 antibodyAnti-PRO1082 antibody |
Information sourced from Uniprot.org