Anti-CD365/KIM-1/TIM-1/HAVCR1 antibody [2.59#] {PerCP} (STJA0030616)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationPerCP
IsotypeIgG1k
General Information
| Short Description | Mouse monoclonal Hepatitis A Virus Cellular Receptor 1 antibody for use in FC in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 2.59# |
| Isotype | IgG1k |
| Conjugation | PerCP |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Formulation | PBS pH 7.4, 50% glycerol, 0.05% proclin300 |
| Storage Instruction | Store at 4°C for 12 months. Protect from light. Do not freeze. |
Target Information
| Gene Symbol | HAVCR1 |
| Gene ID | 26762 |
| Uniprot ID | HAVR1_HUMAN |
Additional Info
| Post Translational Modifications | Ubiquitinated at two lysine residues Lys-338 and Lys-346 on its cytoplasmic domain. Ubiquitination promotes receptor endocytosis and target receptors for lysosomal degradation and termination of receptor signaling. (Microbial infection) Ubiquitination is required for Dengue virus endocytosis. |
| Function | Phosphatidylserine receptor that plays an important functional role in regulatory B-cells homeostasis including generation, expansion and suppressor functions. As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses. Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease. Also regulates expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10. Acts as a regulator of T-cell proliferation. May play a role in kidney injury and repair. (Microbial infection) Acts as a receptor for Hepatitis A virus. (Microbial infection) Acts as a receptor for Ebolavirus and Marburg virus by binding exposed phosphatidyl-serine at the surface of virion membrane. Serves as a dual receptor for Ebolavirus by also interacting with envelope glycoprotein GP. (Microbial infection) Acts as a receptor for Dengue virus by binding exposed phosphatidyl-serine at the surface of virion membrane. TIM1 and Dengue virus are co-internalized during virus entry. (Microbial infection) Acts as a receptor for Zika virus by binding to envelope protein E. (Microbial infection) Plays a positive role in Chikungunya virus cell entry. |
| Protein Name | Hepatitis A Virus Cellular Receptor 1Havcr-1Kidney Injury Molecule 1Kim-1T-Cell Immunoglobulin And Mucin Domain-Containing Protein 1Timd-1T-Cell Immunoglobulin Mucin Receptor 1TimTim-1T-Cell Membrane Protein 1Cd Antigen Cd365 |
| Database Links | Reactome: R-HSA-9694614 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Hepatitis A Virus Cellular Receptor 1 antibodyAnti-Havcr-1 antibodyAnti-Kidney Injury Molecule 1 antibodyAnti-Kim-1 antibodyAnti-T-Cell Immunoglobulin And Mucin Domain-Containing Protein 1 antibodyAnti-Timd-1 antibodyAnti-T-Cell Immunoglobulin Mucin Receptor 1 antibodyAnti-Tim antibodyAnti-Tim-1 antibodyAnti-T-Cell Membrane Protein 1 antibodyAnti-Cd Antigen Cd365 antibodyAnti-HAVCR1 antibodyAnti-KIM1 antibodyAnti-TIM1 antibodyAnti-TIMD1 antibody |
Information sourced from Uniprot.org