Anti-CD349/FZD9 antibody [2933#] (STJA0027266)

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STJA0027266
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Host: Mouse
Applications: FC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal antibody anti-Frizzled-9 is suitable for use in Flow Cytometry research applications.
Clonality : Monoclonal
Clone ID : 2933#
Conjugation: Unconjugated
Isotype: IgG1k
Formulation: 0.01M PBS, pH 7.4.
Purification: Protein A/G purified from cell culture supernatant.
Concentration: 1 mg/ml
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: FZD9
Gene ID: 8326
Uniprot ID: FZD9_HUMAN
Post Translational Modifications Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
Function Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway. May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process. During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling.
Protein Name Frizzled-9
Fz-9
Hfz9
Fze6
Cd Antigen Cd349
Database Links Reactome: R-HSA-373080
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Relocalizes Dvl1 To The Cell Membrane Leading To Phosphorylation Of Dvl1 And Axin1 Relocalization To The Cell Membrane
Alternative Antibody Names Anti-Frizzled-9 antibody
Anti-Fz-9 antibody
Anti-Hfz9 antibody
Anti-Fze6 antibody
Anti-Cd Antigen Cd349 antibody
Anti-FZD9 antibody
Anti-FZD3 antibody

Information sourced from Uniprot.org