![Anti-CD32b/FCGR2B nanobody [SAA1313] (STJN000199)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200812/412994/STJN000199-SDS-PAGE-1__50442.1749232516.jpg?c=1 "Anti-CD32b/FCGR2B nanobody [SAA1313] (STJN000199)")
![Anti-CD32b/FCGR2B nanobody [SAA1313] (STJN000199)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200812/412994/STJN000199-SDS-PAGE-1__50442.1749232516.jpg?c=1 "Anti-CD32b/FCGR2B nanobody [SAA1313] (STJN000199)")
Anti-CD32b/FCGR2B nanobody [SAA1313] (STJN000199)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii-B is suitable for use in ELISA research applications. |
| Applications | ELISA |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1313 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | FCGR2B |
| Gene ID | 2213 |
| Uniprot ID | FCG2B_HUMAN |
Additional Info
| Post Translational Modifications | Phosphorylated by the SRC-type Tyr-kinases LYN and BLK. |
| Function | Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis. |
| Protein Name | Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii-BIgg Fc Receptor Ii-BCdw32Fc-Gamma Rii-BFc-Gamma-RiibFcrii-BCd Antigen Cd32 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Nanobody Names | Anti-Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii-B nanobodyAnti-Igg Fc Receptor Ii-B nanobodyAnti-Cdw32 nanobodyAnti-Fc-Gamma Rii-B nanobodyAnti-Fc-Gamma-Riib nanobodyAnti-Fcrii-B nanobodyAnti-Cd Antigen Cd32 nanobodyAnti-FCGR2B nanobodyAnti-CD32 nanobodyAnti-FCG2 nanobodyAnti-IGFR2 nanobody |
Information sourced from Uniprot.org