| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CD320 |
| Gene ID: | 51293 |
| Uniprot ID: | CD320_HUMAN |
| Immunogen Region: | 36-229 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 36-229 of human CD320 (NP_057663.1). |
| Immunogen Sequence: | SPLSTPTSAQAAGPSSGSCP PTKFQCRTSGLCVPLTWRCD RDLDCSDGSDEEECRIEPCT QKGQCPPPPGLPCPCTGVSD CSGGTDKKLRNCSRLACLAG ELRCTLSDDCIPLTWRCDGH PDCPDSSDELGCGTNEILPE GDATTMGPPVTLESVTSLRN ATTMGPPVTLESVPSVGNAT SSSAGDQSGSPTAY |
| Tissue Specificity | Detected in the germinal center (GC) of lymphoid follicles (at protein level). Expressed abundantly on follicular dendritic cells (FDCs). |
| Function | Receptor for transcobalamin saturated with cobalamin (TCbl). Plays an important role in cobalamin uptake. Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells. Functions as costimulator to promote B cell responses to antigenic stimuli.promotes B cell differentiation and proliferation. Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10. |
| Protein Name | Cd320 Antigen 8d6 Antigen Fdc-Signaling Molecule 8d6 Fdc-Sm-8d6 Transcobalamin Receptor Tcblr Cd Antigen Cd320 |
| Database Links | Reactome: R-HSA-3359485 Reactome: R-HSA-9758890 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Cd320 Antigen antibody Anti-8d6 Antigen antibody Anti-Fdc-Signaling Molecule 8d6 antibody Anti-Fdc-Sm-8d6 antibody Anti-Transcobalamin Receptor antibody Anti-Tcblr antibody Anti-Cd Antigen Cd320 antibody Anti-CD320 antibody Anti-8D6A antibody Anti-UNQ198 antibody Anti-PRO224 antibody |
Information sourced from Uniprot.org