| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CD320 (36-229) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CD320 |
| Gene ID: |
51293 |
| Uniprot ID: |
CD320_HUMAN |
| Immunogen Region: |
36-229 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 36-229 of human CD320 (NP_057663.1). |
| Immunogen Sequence: |
SPLSTPTSAQAAGPSSGSCP PTKFQCRTSGLCVPLTWRCD RDLDCSDGSDEEECRIEPCT QKGQCPPPPGLPCPCTGVSD CSGGTDKKLRNCSRLACLAG ELRCTLSDDCIPLTWRCDGH PDCPDSSDELGCGTNEILPE GDATTMGPPVTLESVTSLRN ATTMGPPVTLESVPSVGNAT SSSAGDQSGSPTAY |
| Tissue Specificity | Detected in the germinal center (GC) of lymphoid follicles (at protein level). Expressed abundantly on follicular dendritic cells (FDCs). |
| Function | Receptor for transcobalamin saturated with cobalamin (TCbl). Plays an important role in cobalamin uptake. Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells. Functions as costimulator to promote B cell responses to antigenic stimuli.promotes B cell differentiation and proliferation. Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10. |
| Protein Name | Cd320 Antigen8d6 AntigenFdc-Signaling Molecule 8d6Fdc-Sm-8d6Transcobalamin ReceptorTcblrCd Antigen Cd320 |
| Database Links | Reactome: R-HSA-3359485Reactome: R-HSA-9758890 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Cd320 Antigen antibodyAnti-8d6 Antigen antibodyAnti-Fdc-Signaling Molecule 8d6 antibodyAnti-Fdc-Sm-8d6 antibodyAnti-Transcobalamin Receptor antibodyAnti-Tcblr antibodyAnti-Cd Antigen Cd320 antibodyAnti-CD320 antibodyAnti-8D6A antibodyAnti-UNQ198 antibodyAnti-PRO224 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
