| Tissue Specificity | Widely expressed by cells of hemopoietic origin. The isoforms are differentially expressed. Isoform IIB1 is preferentially expressed by cells of the lymphoid lineage, isoform IIB2 by cells of the myeloid lineage, and isoform IIB3 is released by macrophages and is present in the serum. Isoform IIB1' is expressed in myeloid and lymphoid cell lines, in normal spleen cells, and in resting or LPS-activated B-cells but is not detected in mesenteric lymph node cells. |
| Post Translational Modifications | Glycosylated. When coaggregated to BCR, isoform IIB1 and isoform IIB1' become tyrosine phosphorylated and bind to the SH2 domains of the protein tyrosine phosphatase PTPC1. Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN and SYK. |
| Function | Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of antigen-antibody complexes from the circulation and modulation of antibody production by B-cells. Isoform IIB1 and isoform IIB1' form caps but fail to mediate endocytosis or phagocytosis. Isoform IIB2 can mediate the endocytosis of soluble immune complexes via clathrin-coated pits. Isoform IIB1 and isoform IIB2 can down-regulate B-cell, T-cell, and mast cell activation when coaggregated to B-cell receptors for AG (BCR), T-cell receptors for AG (TCR), and Fc receptors, respectively. |
| Protein Name | Low Affinity Immunoglobulin Gamma Fc Region Receptor IiFc Gamma Receptor IibFc-Gamma RiiFc-Gamma-RiibFcriiIgg Fc Receptor Ii BetaLymphocyte Antigen 17Ly-17Cd Antigen Cd32 |
| Database Links | Reactome: R-MMU-198933Reactome: -MMU-2029481Reactome: -MMU-2029482Reactome: -MMU-2029485Reactome: -MMU-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinIsoform Iib1: CytoplasmCytoskeletonBinds The Cytoskeleton And Is Not Localized In Endocytotic PitsIsoform Iib3: SecretedReleased As A Soluble Molecule |
| Alternative Antibody Names | Anti-Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii antibodyAnti-Fc Gamma Receptor Iib antibodyAnti-Fc-Gamma Rii antibodyAnti-Fc-Gamma-Riib antibodyAnti-Fcrii antibodyAnti-Igg Fc Receptor Ii Beta antibodyAnti-Lymphocyte Antigen 17 antibodyAnti-Ly-17 antibodyAnti-Cd Antigen Cd32 antibodyAnti-Fcgr2 antibodyAnti-Fcgr2b antibodyAnti-Ly-17 antibody |
Information sourced from Uniprot.org
