Anti-CD304/NRP1/NRP2 antibody [YW681126] {FITC} (STJA0027923)
SPECIFICATIONS
ClonalityMonoclonal
HostRat
ConjugationFITC
IsotypeIgG1k
General Information
| Short Description | Rat monoclonal CD304/NRP1/NRP2 antibody for use in ELISA and FC in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/FC |
| Host | Rat |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | YW681126 |
| Isotype | IgG1k |
| Conjugation | FITC |
| Concentration | 05 mg/mL |
| Purification | Purified |
| Formulation | PBS pH 7.4, 50% glycerol, 0.05% proclin300 |
| Storage Instruction | Store at 4°C for 12 months Protect from light Do not freeze |
Target Information
| Gene Symbol | Nrp1 |
| Gene ID | 18186 |
| Uniprot ID | NRP1_MOUSE |
Additional Info
| Function | Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins. Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage. Binds to semaphorin 3A (SEMA3A), the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR. |
| Protein Name | Neuropilin-1A5 ProteinCd Antigen Cd304 |
| Database Links | Reactome: R-MMU-194306Reactome: -MMU-399954Reactome: -MMU-399955Reactome: -MMU-399956Reactome: -MMU-445144 |
| Cellular Localisation | Mitochondrion MembraneSingle-Pass Type I Membrane ProteinCell MembraneCytoplasm |
| Alternative Antibody Names | Anti-Neuropilin-1 antibodyAnti-A5 Protein antibodyAnti-Cd Antigen Cd304 antibodyAnti-Nrp1 antibodyAnti-Nrp antibody |
Information sourced from Uniprot.org