Anti-CD304/Neuropilin-1 antibody {ABflo® 450} (STJ11108986)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationABflo® 450
IsotypeIgG
ImmunogenRecombinant protein (or fragment).This information is considered to be commercially sensitive.
General Information
| Short Description | Rabbit monoclonal CD304/Neuropilin-1 antibody for use in FC in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Isotype | IgG |
| Conjugation | ABflo® 450 |
| Purification | Affinity purification |
| Dilution Range | FC, 5 Mu l per 10^6 cells in 100 Mu l volume |
| Formulation | PBS with 0.09% Sodium azide, 0.2% BSA, pH7.3. |
| Storage Instruction | Store at 4°C for up to 1 year from the date of receipt. Do not freeze. |
Target Information
| Gene Symbol | Nrp1 |
| Gene ID | 18186 |
| Uniprot ID | NRP1_MOUSE |
| Immunogen | Recombinant protein (or fragment).This information is considered to be commercially sensitive. |
Additional Info
| Tissue Specificity | Nervous system. |
| Function | Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins. Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage. Binds to semaphorin 3A (SEMA3A), the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR. |
| Protein Name | Neuropilin-1A5 ProteinCd Antigen Cd304 |
| Database Links | Reactome: R-MMU-194306Reactome: -MMU-399954Reactome: -MMU-399955Reactome: -MMU-399956Reactome: -MMU-445144 |
| Cellular Localisation | Mitochondrion MembraneSingle-Pass Type I Membrane ProteinCell MembraneCytoplasm |
| Alternative Antibody Names | Anti-Neuropilin-1 antibodyAnti-A5 Protein antibodyAnti-Cd Antigen Cd304 antibodyAnti-Nrp1 antibodyAnti-Nrp antibody |
Information sourced from Uniprot.org