Anti-CD304/Neuropilin-1 antibody (22-856 aa) [SRM5459] (STJ11107373)

Name: Anti-CD304/Neuropilin-1 antibody (22-856 aa) [SRM5459] (STJ11107373)
SKU: STJ11107373
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⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityMonoclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ11107373

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Short Description	Rabbit monoclonal CD304/Neuropilin-1 (22-856 aa) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Monoclonal
Clone ID	SRM5459
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:1000-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	Nrp1
Gene ID	18186
Uniprot ID	NRP1_MOUSE
Immunogen Region	22-856 aa
Immunogen Sequence	FRSDKCGGTIKIENPGYLTS PGYPHSYHPSEKCEWLIQAP EPYQRIMINFNPHFDLEDRD CKYDYVEVIDGENEGGRLWG KFCGKIAPSPVVSSGPFLFI KFVSDYETHGAGFSIRYEIF KRGPECSQNYTAPTGVIKSP GFPEKYPNSLECTYIIFAPK MSEIILEFESFDLEQDSNPP GGMFCRYDRLEIWDGFPEVG PHIGRYCGQKTPGRIRSSSG VLSMVFYTDSAIAKEGFSA
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 22-856 of mouse CD304/Neuropilin-1 (NP_032763.2).

Tissue Specificity	Nervous system.
Function	Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins. Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage. Binds to semaphorin 3A (SEMA3A), the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR.
Protein Name	Neuropilin-1 A5 Protein Cd Antigen Cd304
Database Links	Reactome: R-MMU-194306 Reactome: -MMU-399954 Reactome: -MMU-399955 Reactome: -MMU-399956 Reactome: -MMU-445144
Cellular Localisation	Mitochondrion Membrane Single-Pass Type I Membrane Protein Cell Membrane Cytoplasm
Alternative Antibody Names	Anti-Neuropilin-1 antibody Anti-A5 Protein antibody Anti-Cd Antigen Cd304 antibody Anti-Nrp1 antibody Anti-Nrp antibody

Information sourced from Uniprot.org