| Host: |
Mouse |
| Applications: |
FC |
| Reactivity: |
Human |
| Note: |
FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-C-type lectin domain family 4 member C is suitable for use in Flow Cytometry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
201A |
| Conjugation: |
APC |
| Isotype: |
IgG2ak |
| Formulation: |
PBS with 0.05% Proclin300, 1% BSA |
| Storage Instruction: |
Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
| Tissue Specificity | Expressed in plasmacytoid dendritic cells (PDCs). Constitutively expressed in immature monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not with TNF-alpha. |
| Function | Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells. Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man. Binds to serum IgG. Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium. |
| Protein Name | C-Type Lectin Domain Family 4 Member CBlood Dendritic Cell Antigen 2Bdca-2C-Type Lectin Superfamily Member 7Dendritic LectinCd Antigen Cd303 |
| Database Links | Reactome: R-HSA-5621480Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-C-Type Lectin Domain Family 4 Member C antibodyAnti-Blood Dendritic Cell Antigen 2 antibodyAnti-Bdca-2 antibodyAnti-C-Type Lectin Superfamily Member 7 antibodyAnti-Dendritic Lectin antibodyAnti-Cd Antigen Cd303 antibodyAnti-CLEC4C antibodyAnti-BDCA2 antibodyAnti-CLECSF11 antibodyAnti-CLECSF7 antibodyAnti-DLEC antibodyAnti-HECL antibodyAnti-UNQ9361 antibodyAnti-PRO34150 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
