| Post Translational Modifications | Phosphorylated on tyrosine. |
| Function | Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition.recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis. Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands. May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2. Inhibits osteoclast formation. Induces macrophage cell death upon engagement. |
| Protein Name | Cmrf35-Like Molecule 1Clm-1Cd300 Antigen-Like Family Member FImmune Receptor Expressed On Myeloid Cells 1Irem-1Immunoglobulin Superfamily Member 13Igsf13Nk Inhibitory ReceptorCd Antigen Cd300f |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Cmrf35-Like Molecule 1 antibodyAnti-Clm-1 antibodyAnti-Cd300 Antigen-Like Family Member F antibodyAnti-Immune Receptor Expressed On Myeloid Cells 1 antibodyAnti-Irem-1 antibodyAnti-Immunoglobulin Superfamily Member 13 antibodyAnti-Igsf13 antibodyAnti-Nk Inhibitory Receptor antibodyAnti-Cd Antigen Cd300f antibodyAnti-CD300LF antibodyAnti-CD300F antibodyAnti-CLM1 antibodyAnti-IGSF13 antibodyAnti-IREM1 antibodyAnti-NKIR antibodyAnti-UNQ3105 antibodyAnti-PRO10111 antibody |
Information sourced from Uniprot.org
