Anti-CD2AP antibody (320-400 aa) (STJ191673)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 320-400
General Information
| Short Description | Rabbit polyclonal anti-CD2-associated protein (320-400 aa) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CD2AP |
| Gene ID | 23607 |
| Uniprot ID | CD2AP_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 320-400 |
| Immunogen Region | 320-400 aa |
| Specificity | CD2AP Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Phosphorylated on tyrosine residues.probably by c-Abl, Fyn and c-Src. |
| Function | Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis. Plays a role in epithelial cell junctions formation. |
| Protein Name | Cd2-Associated ProteinAdapter Protein CmsCas Ligand With Multiple Sh3 Domains |
| Database Links | Reactome: R-HSA-373753 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionRuffleCell JunctionColocalizes With F-Actin And Bcar1/P130cas In Membrane RufflesLocated At Podocyte Slit Diaphragm Between Podocyte Foot ProcessesDuring Late Anaphase And TelophaseConcentrates In The Vicinity Of The Midzone Microtubules And In The Midbody In Late Telophase |
| Alternative Antibody Names | Anti-Cd2-Associated Protein antibodyAnti-Adapter Protein Cms antibodyAnti-Cas Ligand With Multiple Sh3 Domains antibodyAnti-CD2AP antibody |
Information sourced from Uniprot.org