Anti-CD288/TLR8/PRO286 antibody [SAA1960] (STJA0020388)

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STJA0020388
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Host: Mouse
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS
Short Description : Mouse monoclonal antibody anti-Toll-Like Receptor 8 is suitable for use in ELISA research applications.
Clonality : Monoclonal
Clone ID : SAA1960
Conjugation: Unconjugated
Isotype: IgG2a
Formulation: 0.01M PBS
Purification: Protein A/G purified from cell culture supernatant
Concentration: 1 mg/mL
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months
Gene Symbol: TLR8
Gene ID: 51311
Uniprot ID: TLR8_HUMAN
Post Translational Modifications Ubiquitinated by RNF216.leading to degradation by the proteasome. Proteolytic processing occurs in monocytes and monocyte-derived macrophages by both furin-like proprotein convertase and cathepsins. The cleavage is necessary for dimer formation and subsequent activation.
Function Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2. Recognizes GU-rich single-stranded RNA (GU-rich RNA) derived from SARS-CoV-2, SARS-CoV-1 and HIV-1 viruses. Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction. In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively.
Protein Name Toll-Like Receptor 8
Cd Antigen Cd288
Database Links Reactome: R-HSA-1679131
Reactome: R-HSA-168181
Reactome: R-HSA-9705671
Cellular Localisation Endosome Membrane
Single-Pass Type I Membrane Protein
Endosomal Localization Confers Distinctive Proteolytic Processing
Alternative Antibody Names Anti-Toll-Like Receptor 8 antibody
Anti-Cd Antigen Cd288 antibody
Anti-TLR8 antibody
Anti-UNQ249 antibody
Anti-PRO286 antibody

Information sourced from Uniprot.org