![Anti-CD28 antibody [CD28.2] {PE} (STJA0002114)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/147898/292877/STJA0002114_1__14075.1631206900.jpg?c=1 "Anti-CD28 antibody [CD28.2] {PE} (STJA0002114)")
![Anti-CD28 antibody [CD28.2] {PE} (STJA0002114)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/147898/292877/STJA0002114_1__14075.1631206900.jpg?c=1 "Anti-CD28 antibody [CD28.2] {PE} (STJA0002114)")
Anti-CD28 antibody [CD28.2] {PE} (STJA0002114)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationPE
IsotypeIgG1k
General Information
| Short Description | Mouse monoclonal anti-T-cell-specific surface glycoprotein CD28 for use in FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Mouse |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | CD28.2 |
| Isotype | IgG1k |
| Conjugation | PE |
| Concentration | 5 Mu L/Test |
| Formulation | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Storage Instruction | Store between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
Target Information
| Gene Symbol | CD28 |
| Gene ID | 940 |
| Uniprot ID | CD28_HUMAN |
Additional Info
| Tissue Specificity | Expressed in T-cells and plasma cells, but not in less mature B-cells. |
| Post Translational Modifications | Phosphorylated by LCK. Dephosphorylated by PTPN11. Isoform 3: Tyrosine phosphorylated induced by CD40LG. |
| Function | Receptor that plays a role in T-cell activation, proliferation, survival and the maintenance of immune homeostasis. Functions not only as an amplifier of TCR signals but delivers unique signals that control intracellular biochemical events that alter the gene expression program of T-cells. Stimulation upon engagement of its cognate ligands CD80 or CD86 increases proliferation and expression of various cytokines in particular IL2 production in both CD4(+) and CD8(+) T-cell subsets. Mechanistically, ligation induces recruitment of protein kinase C-theta/PRKCQ and GRB2 leading to NF-kappa-B activation via both PI3K/Akt-dependent and -independent pathways. In conjunction with TCR/CD3 ligation and CD40L costimulation, enhances the production of IL4 and IL10 in T-cells. Isoform 3: Enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. |
| Protein Name | T-Cell-Specific Surface Glycoprotein Cd28Tp44Cd Antigen Cd28 |
| Database Links | Reactome: R-HSA-1257604Reactome: R-HSA-164939Reactome: R-HSA-2219530Reactome: R-HSA-389356Reactome: R-HSA-389357Reactome: R-HSA-389359Reactome: R-HSA-6811558 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 3: Cell Surface |
| Alternative Antibody Names | Anti-T-Cell-Specific Surface Glycoprotein Cd28 antibodyAnti-Tp44 antibodyAnti-Cd Antigen Cd28 antibodyAnti-CD28 antibody |
Information sourced from Uniprot.org