Anti-CD276/B7-H3 nanobody [SAA2193] (STJN000633)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-6His
General Information
| Short Description | Alpaca monoclonal nanobody anti-Cd276 antigen is suitable for use in ELISA research applications. |
| Applications | ELISA |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA2193 |
| Isotype | VHH-6His |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | CD276 |
| Gene ID | 80381 |
| Uniprot ID | CD276_HUMAN |
Additional Info
| Function | May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. |
| Protein Name | Cd276 Antigen4ig-B7-H3B7 Homolog 3B7-H3Costimulatory MoleculeCd Antigen Cd276 |
| Database Links | |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Nanobody Names | Anti-Cd276 Antigen nanobodyAnti-4ig-B7-H3 nanobodyAnti-B7 Homolog 3 nanobodyAnti-B7-H3 nanobodyAnti-Costimulatory Molecule nanobodyAnti-Cd Antigen Cd276 nanobodyAnti-CD276 nanobodyAnti-B7H3 nanobodyAnti-PSEC0249 nanobodyAnti-UNQ309 nanobodyAnti-PRO352 nanobody |
Information sourced from Uniprot.org