Anti-CD276/B7-H3 antibody [SAA2010] (STJA0020557)
SPECIFICATIONS
ClonalityMonoclonal
HostHuman
ConjugationUnconjugated
IsotypeIgG1
General Information
| Short Description | Human monoclonal Cd276 antigen antibody for use in ELISA, FC and WB in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/FC/WB |
| Host | Human |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA2010 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1.42 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | CD276 |
| Gene ID | 80381 |
| Uniprot ID | CD276_HUMAN |
Additional Info
| Function | May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. |
| Protein Name | Cd276 Antigen4ig-B7-H3B7 Homolog 3B7-H3Costimulatory MoleculeCd Antigen Cd276 |
| Database Links | |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Cd276 Antigen antibodyAnti-4ig-B7-H3 antibodyAnti-B7 Homolog 3 antibodyAnti-B7-H3 antibodyAnti-Costimulatory Molecule antibodyAnti-Cd Antigen Cd276 antibodyAnti-CD276 antibodyAnti-B7H3 antibodyAnti-PSEC0249 antibodyAnti-UNQ309 antibodyAnti-PRO352 antibody |
Information sourced from Uniprot.org