Anti-CD272/BTLA antibody [SAA0087] (STJA0027208)
SPECIFICATIONS
ClonalityMonoclonal
HostHuman
ConjugationUnconjugated
IsotypeIgG4k
General Information
| Short Description | Human monoclonal B-And T-Lymphocyte Attenuator antibody for use in FC in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Human |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA0087 |
| Isotype | IgG4k |
| Conjugation | Unconjugated |
| Concentration | 1 mg/ml |
| Purification | Protein A/G purified from cell culture supernatant. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | BTLA |
| Gene ID | 151888 |
| Uniprot ID | BTLA_HUMAN |
Additional Info
| Function | Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells. |
| Protein Name | B- And T-Lymphocyte AttenuatorB- And T-Lymphocyte-Associated ProteinCd Antigen Cd272 |
| Database Links | Reactome: R-HSA-9927353 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-B- And T-Lymphocyte Attenuator antibodyAnti-B- And T-Lymphocyte-Associated Protein antibodyAnti-Cd Antigen Cd272 antibodyAnti-BTLA antibody |
Information sourced from Uniprot.org