Anti-CD27 antibody [R08-6V-6] (STJA0033097)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenPeptide
General Information
| Short Description | Mouse monoclonal anti-CD27 for use in ICC, IF and FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ICC/IF/FC |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R08-6V-6 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Purification | Protein G |
| Dilution Range | ICC:IF 1:50FC 1:50-1:100 |
| Formulation | Liquid in PBS, Glycerol and BSA |
| Storage Instruction | Store at-20°C. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | CD27 |
| Gene ID | 939 |
| Uniprot ID | CD27_HUMAN |
| Immunogen | Peptide |
Additional Info
| Tissue Specificity | Found in most T-lymphocytes. |
| Post Translational Modifications | Phosphorylated. N-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. |
| Function | Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells. The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells. Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory. In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis. Negatively regulates the function of Th2 lymphocytes in the adipose tissue. |
| Protein Name | Cd27 AntigenCd27l ReceptorT-Cell Activation Antigen Cd27T14Tumor Necrosis Factor Receptor Superfamily Member 7Cd Antigen Cd27 |
| Database Links | Reactome: R-HSA-5669034 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Cd27 Antigen antibodyAnti-Cd27l Receptor antibodyAnti-T-Cell Activation Antigen Cd27 antibodyAnti-T14 antibodyAnti-Tumor Necrosis Factor Receptor Superfamily Member 7 antibodyAnti-Cd Antigen Cd27 antibodyAnti-CD27 antibodyAnti-TNFRSF7 antibody |
Information sourced from Uniprot.org