Anti-CD27 antibody [LG.3A10] {EF647} (STJA0042346)
SPECIFICATIONS
ClonalityMonoclonal
HostArmenian Hamster
ConjugationEF647
IsotypeIgG
General Information
| Short Description | Armenian Hamster monoclonal anti-CD27 for use in FC in Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Armenian Hamster |
| Reactivity | Mouse |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | LG.3A10 |
| Isotype | IgG |
| Conjugation | EF647 |
| Concentration | 5 Mu L/Test |
| Formulation | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Storage Instruction | Store between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
Target Information
| Gene Symbol | Cd27 |
| Gene ID | 21940 |
| Uniprot ID | CD27_MOUSE |
Additional Info
| Tissue Specificity | In thymus and spleen, but not in non-lymphoid tissues. Expressed on myeloid progenitor cells. |
| Post Translational Modifications | Phosphorylated. N-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. |
| Function | Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells. The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells. Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory. In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis. Negatively regulates the function of Th2 lymphocytes in the adipose tissue. |
| Protein Name | Cd27 AntigenCd27l ReceptorT-Cell Activation Antigen Cd27Tumor Necrosis Factor Receptor Superfamily Member 7Cd Antigen Cd27 |
| Database Links | Reactome: R-MMU-5669034 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Cd27 Antigen antibodyAnti-Cd27l Receptor antibodyAnti-T-Cell Activation Antigen Cd27 antibodyAnti-Tumor Necrosis Factor Receptor Superfamily Member 7 antibodyAnti-Cd Antigen Cd27 antibodyAnti-Cd27 antibodyAnti-Tnfrsf7 antibody |
Information sourced from Uniprot.org