Anti-CD262/TRAILR2 antibody {PE} (STJ11108732)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationPE
IsotypeIgG
ImmunogenRecombinant protein (or fragment).This information is considered to be commercially sensitive.
General Information
| Short Description | Rabbit monoclonal CD262/TRAILR2 antibody for use in FC in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Isotype | IgG |
| Conjugation | PE |
| Purification | Affinity purification |
| Dilution Range | FC, 5 Mu l per 10^6 cells in 100 Mu l volume |
| Formulation | PBS containing 0.2% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis) , pH 7.3. |
| Storage Instruction | Store at 4°C for up to 1 year from the date of receipt. Do not freeze. |
Target Information
| Gene Symbol | Tnfrsf10b |
| Gene ID | 21933 |
| Uniprot ID | TR10B_MOUSE |
| Immunogen | Recombinant protein (or fragment).This information is considered to be commercially sensitive. |
Additional Info
| Tissue Specificity | Highly expressed in heart, lung and kidney. |
| Post Translational Modifications | (Microbial infection) Glycosylated at Arg-293 by S.typhimurium protein Ssek3. |
| Function | Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 10bDeath Receptor 5MkCd Antigen Cd262 |
| Database Links | Reactome: R-MMU-202733Reactome: -MMU-3371378Reactome: -MMU-5218900Reactome: -MMU-69416Reactome: -MMU-75158 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Receptor Superfamily Member 10b antibodyAnti-Death Receptor 5 antibodyAnti-Mk antibodyAnti-Cd Antigen Cd262 antibodyAnti-Tnfrsf10b antibodyAnti-Dr5 antibodyAnti-Killer antibody |
Information sourced from Uniprot.org