Anti-CD262/TNFRSF10B/TRAIL-R2 antibody [SAA1413] {APC} (STJA0028886)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationAPC
IsotypeIgG2ak
General Information
| Short Description | Mouse monoclonal Tumor Necrosis Factor Receptor Superfamily Member 10b antibody for use in FC in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1413 |
| Isotype | IgG2ak |
| Conjugation | APC |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Formulation | PBS pH 7.4, 50% glycerol, 0.05% proclin300 |
| Storage Instruction | Store at 4°C for 12 months. Protect from light. Do not freeze. |
Target Information
| Gene Symbol | TNFRSF10B |
| Gene ID | 8795 |
| Uniprot ID | TR10B_HUMAN |
Additional Info
| Post Translational Modifications | (Microbial infection) Glycosylated on Arg residue by S.typhimurium protein Ssek3. |
| Function | Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 10bDeath Receptor 5Tnf-Related Apoptosis-Inducing Ligand Receptor 2Trail Receptor 2Trail-R2Cd Antigen Cd262 |
| Database Links | Reactome: R-HSA-140534Reactome: R-HSA-202733Reactome: R-HSA-3371378Reactome: R-HSA-5213460Reactome: R-HSA-5218900Reactome: R-HSA-6803211Reactome: R-HSA-69416Reactome: R-HSA-75158 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Receptor Superfamily Member 10b antibodyAnti-Death Receptor 5 antibodyAnti-Tnf-Related Apoptosis-Inducing Ligand Receptor 2 antibodyAnti-Trail Receptor 2 antibodyAnti-Trail-R2 antibodyAnti-Cd Antigen Cd262 antibodyAnti-TNFRSF10B antibodyAnti-DR5 antibodyAnti-KILLER antibodyAnti-TRAILR2 antibodyAnti-TRICK2 antibodyAnti-ZTNFR9 antibodyAnti-UNQ160 antibodyAnti-PRO186 antibody |
Information sourced from Uniprot.org