| Host: |
Mouse |
| Applications: |
IHC-F/FC/IF/IP/IHC-P |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-CD243 is suitable for use in Immunohistochemistry, Flow Cytometry, Immunofluorescence, Immunoprecipitation and Immunohistochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
UIC2 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG2a |
| Formulation: |
PBS with <0.1% sodium azide |
| Purification: |
Purified |
| Concentration: |
1 mg/mL |
| Storage Instruction: |
Store aliquots at-20°C, and thawed aliquots at 2-8°C. |
| Immunogen: |
Mouse Balb/c 3T3 fibroblasts transfected with human CD243 cDNA |
| Background | Mouse anti Human CD243, clone UIC2 recognizes an extracellular conformational epitope of CD243, also known as MDR1 (multi-drug resistance protein 1) and Pgp (P-glycoprotein) , a multi pass transmembrane protein and member of the ABC transporter (ATP-binding cassette) family, containing two ABC transporter type 1 domains and two ABC transporter domains. CD243 acts as an active efflux pump for a diverse range of lipophillic compounds. CD243 is expressed at low levels in the cell membrane of peripheral blood leucocytes, and constitutively expressed on the apical plasma membrane of excretory epithelial cells of the kidney, liver, brain and small intestine. CD243 mediates resistance to many chemotherapeutic agents used for tumour suppression and is therefore of special interest to oncologists. Clone UIC2 is a strong inhibitor of CD243-mediated efflux and of the resistance of MDR cells to CD243 transported cytotoxic drugs. |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
