Anti-CD24 antibody (1-80 aa) [SRM5460] (STJ11107374)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal CD24 (1-80 aa) antibody for use in IF, ICC and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM5460 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | IF/ICC:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CD24 |
| Gene ID | 100133941 |
| Uniprot ID | CD24_HUMAN |
| Immunogen Region | 1-80 aa |
| Immunogen Sequence | MGRAMVARLGLGLLLLALLL PTQIYSSETTTGTSSNSSQS TSNSGLAPNPTNATTKAAGG ALQSTASLFVVSLSLLHLYS |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-80 of human CD24 (NP_037362.1). |
Additional Info
| Tissue Specificity | B-cells. Expressed in a number of B-cell lines including P32/ISH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells. |
| Post Translational Modifications | Extensively O-glycosylated. |
| Function | May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity. |
| Protein Name | Signal Transducer Cd24Small Cell Lung Carcinoma Cluster 4 AntigenCd Antigen Cd24 |
| Database Links | Reactome: R-HSA-373760 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-Anchor |
| Alternative Antibody Names | Anti-Signal Transducer Cd24 antibodyAnti-Small Cell Lung Carcinoma Cluster 4 Antigen antibodyAnti-Cd Antigen Cd24 antibodyAnti-CD24 antibodyAnti-CD24A antibody |
Information sourced from Uniprot.org