Anti-CD239/BCAM antibody {ABflo® 647} (STJ11108554)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationABflo® 647
IsotypeIgG
ImmunogenRecombinant protein (or fragment).This information is considered to be commercially sensitive.
General Information
| Short Description | Rabbit monoclonal CD239/BCAM antibody for use in FC in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Isotype | IgG |
| Conjugation | ABflo® 647 |
| Purification | Affinity purification |
| Dilution Range | FC, 5 Mu l per 10^6 cells in 100 Mu l volume |
| Formulation | PBS containing 0.2% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis) , pH 7.3. |
| Storage Instruction | Store at 4°C for up to 1 year from the date of receipt. Do not freeze. |
Target Information
| Gene Symbol | BCAM |
| Gene ID | 4059 |
| Uniprot ID | BCAM_HUMAN |
| Immunogen | Recombinant protein (or fragment).This information is considered to be commercially sensitive. |
Additional Info
| Tissue Specificity | Wide tissue distribution (highest in the pancreas and very low in brain). Closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls. |
| Post Translational Modifications | Epinephrine-stimulated phosphorylation of Ser-621 by PKA enhances adhesion to laminin. Ser-621 can also be phosphorylated by AKT1. |
| Function | Transmembrane glycoprotein that functions as both a receptor and an adhesion molecule playing a crucial role in cell adhesion, motility, migration and invasion. Extracellular domain enables binding to extracellular matrix proteins, such as laminin, integrin and other ligands while its intracellular domain interacts with cytoskeletal proteins like hemoglobin, facilitating cell signal transduction. Serves as a receptor for laminin alpha-5/LAMA5 to promote cell adhesion. Mechanistically, JAK2 induces BCAM phosphorylation and activates its adhesion to laminin by stimulating a Rap1/AKT signaling pathway in the absence of EPOR. |
| Protein Name | Basal Cell Adhesion MoleculeAuberger B AntigenB-Cam Cell Surface GlycoproteinF8/G253 AntigenLutheran AntigenLutheran Blood Group GlycoproteinCd Antigen Cd239 |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Basal Cell Adhesion Molecule antibodyAnti-Auberger B Antigen antibodyAnti-B-Cam Cell Surface Glycoprotein antibodyAnti-F8/G253 Antigen antibodyAnti-Lutheran Antigen antibodyAnti-Lutheran Blood Group Glycoprotein antibodyAnti-Cd Antigen Cd239 antibodyAnti-BCAM antibodyAnti-LU antibodyAnti-MSK19 antibody |
Information sourced from Uniprot.org