![Anti-CD23 antibody [SM5144] (STJA0005144)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/180196/403637/STJA0005144_1__22916.1738950642.png?c=1 "Anti-CD23 antibody [SM5144] (STJA0005144)")
![Anti-CD23 antibody [SM5144] (STJA0005144)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/180196/403637/STJA0005144_1__22916.1738950642.png?c=1 "Anti-CD23 antibody [SM5144] (STJA0005144)")
Anti-CD23 antibody [SM5144] (STJA0005144)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
ImmunogenSynthesized peptide derived from human CD23
General Information
| Short Description | Mouse monoclonal anti-CD23 for use in IHC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SM5144 |
| Conjugation | Unconjugated |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range | IHC/IF (H) 1:200-1:500 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage Instruction | Store at-20C for up to one year, and avoid repeated freeze-thaw cycles. |
Target Information
| Gene Symbol | FCER2 |
| Gene ID | 2208 |
| Uniprot ID | FCER2_HUMAN |
| Immunogen | Synthesized peptide derived from human CD23 |
Additional Info
| Post Translational Modifications | N- and O-glycosylated. The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding. |
| Function | Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B cells. On B cells, initiates IgE-dependent antigen uptake and presentation to T cells. On macrophages, upon IgE binding and antigen cross-linking induces intracellular killing of parasites through activation of L-Arginine-nitric oxide pathway. |
| Protein Name | Low Affinity Immunoglobulin Epsilon Fc ReceptorBlast-2C-Type Lectin Domain Family 4 Member JFc-Epsilon-RiiImmunoglobulin E-Binding FactorLymphocyte Ige ReceptorCd Antigen Cd23 Cleaved Into - Low Affinity Immunoglobulin Epsilon Fc Receptor Membrane-Bound Form - Low Affinity Immunoglobulin Epsilon Fc Receptor Soluble Form |
| Database Links | Reactome: R-HSA-2197563Reactome: R-HSA-6783783Reactome: R-HSA-6785807 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinLipid-AnchorSecretedAlso Exists As A Soluble Excreted FormScd23 |
| Alternative Antibody Names | Anti-Low Affinity Immunoglobulin Epsilon Fc Receptor antibodyAnti-Blast-2 antibodyAnti-C-Type Lectin Domain Family 4 Member J antibodyAnti-Fc-Epsilon-Rii antibodyAnti-Immunoglobulin E-Binding Factor antibodyAnti-Lymphocyte Ige Receptor antibodyAnti-Cd Antigen Cd23 Cleaved Into - Low Affinity Immunoglobulin Epsilon Fc Receptor Membrane-Bound Form - Low Affinity Immunoglobulin Epsilon Fc Receptor Soluble Form antibodyAnti-FCER2 antibodyAnti-CD23A antibodyAnti-CLEC4J antibodyAnti-FCE2 antibodyAnti-IGEBF antibody |
Information sourced from Uniprot.org