![Anti-CD23 antibody [1B12] (STJ16100331)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/149048/346664/STJ16100331_1__01343.1681998742.jpg?c=1 "Anti-CD23 antibody [1B12] (STJ16100331)")
![Anti-CD23 antibody [1B12] (STJ16100331)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/149048/346664/STJ16100331_1__01343.1681998742.jpg?c=1 "Anti-CD23 antibody [1B12] (STJ16100331)")
Anti-CD23 antibody [1B12] (STJ16100331)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
General Information
| Short Description | Mouse monoclonal anti-CD23 for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 1B12 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Dilution Range | IHC-P 1:10-1:50 |
| Formulation | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
Additional Info
| Background | CD23 antigen is a 45-60 kDa membrane glycoprotein identified as a low affinity receptor for IgE production as well as a receptor for lymphocyte growth factor. CD23 is found in some mature B-cell lymphomas and in Reed-Sternberg cells in Hodgkin disease. Follicular dendritic cells and some activated B-cells within germinal centers express CD23 in high density and mantle zone B-cells are stained. The majority of chronic lymphocytic leukemias/small lymphocytic lymphomas are anti-CD23 positive, whereas mantle cell lymphomas are generally negative, so this marker is useful when applied with other markers to separate the small cell lymphomas.1, 3 Precursor B and T lymphomas, myeloid neoplasms, and mature T-cell lymphomas are CD23 negative and other small cell lymphomas are occasionally positive. Anti-CD23 is expressed in activated mature B-cells expressing IgM or IgD, monocytes/macrophages, follicular dendritic cells, T-cell subsets, eosinophils, Langerhans cells and small lymphocytic lymphoma/chronic lymphocytic leukemia. |
Information sourced from Uniprot.org