Anti-CD22 antibody [RFB4] {PE} (STJ16100032)

SKU:
STJ16100032-05

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Host: Mouse
Applications: FC
Reactivity: Human/Dog
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-CD22 is suitable for use in Flow Cytometry research applications.
Clonality: Monoclonal
Clone ID: RFB4
Conjugation: PE
Isotype: IgG1
Formulation: PBS with 4mg/ml BSA and 0.1% sodium azide
Storage Instruction: Store at 2-8°C upon receipt.
Gene Symbol: CD22
Gene ID: 933
Uniprot ID: CD22_HUMAN
Immunogen: Human CD22
Tissue Specificity B-lymphocytes.
Post Translational Modifications Phosphorylation of Tyr-762, Tyr-807 and Tyr-822 are involved in binding to SYK, GRB2 and SYK, respectively. Phosphorylation of Tyr-842 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2. Phosphorylated on tyrosine residues by LYN.
Function Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins.one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Protein Name B-Cell Receptor Cd22
B-Lymphocyte Cell Adhesion Molecule
Bl-Cam
Sialic Acid-Binding Ig-Like Lectin 2
Siglec-2
T-Cell Surface Antigen Leu-14
Cd Antigen Cd22
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-5690714
Reactome: R-HSA-983695
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-B-Cell Receptor Cd22 antibody
Anti-B-Lymphocyte Cell Adhesion Molecule antibody
Anti-Bl-Cam antibody
Anti-Sialic Acid-Binding Ig-Like Lectin 2 antibody
Anti-Siglec-2 antibody
Anti-T-Cell Surface Antigen Leu-14 antibody
Anti-Cd Antigen Cd22 antibody
Anti-CD22 antibody
Anti-SIGLEC2 antibody

Information sourced from Uniprot.org

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