Anti-CD210/Il10ra antibody [1B1.3A] {Biotin} (STJA0001420)

SKU:
STJA0001420

Current Stock:
Host: Rat
Applications: FC
Reactivity: Mouse
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Rat monoclonal antibody anti-Interleukin-10 receptor subunit alpha is suitable for use in Flow Cytometry research applications.
Clonality: Monoclonal
Clone ID: 1B1.3A
Conjugation: Biotin
Isotype: IgG1k
Formulation: PBS with 0.05% Proclin300, 1% BSA
Concentration: 0.5 mg/mL
Storage Instruction: Store at 2-8°C. Do not freeze this product.
Gene Symbol: Il10ra
Gene ID: 16154
Uniprot ID: I10R1_MOUSE
Post Translational Modifications Phosphorylated. Phosphorylation of the cytoplasmic tail induced STAT3 activation. Ubiquitinated by BTRC.ubiquitination leads to endocytosis and subsequent degradation of IL10RA.
Function Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well. In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively. These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy.
Protein Name Interleukin-10 Receptor Subunit Alpha
Il-10 Receptor Subunit Alpha
Il-10r Subunit Alpha
Il-10ra
Cdw210a
Interleukin-10 Receptor Subunit 1
Il-10r Subunit 1
Il-10r1
Cd Antigen Cd210
Database Links Reactome: R-MMU-6783783
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cytoplasm
Alternative Antibody Names Anti-Interleukin-10 Receptor Subunit Alpha antibody
Anti-Il-10 Receptor Subunit Alpha antibody
Anti-Il-10r Subunit Alpha antibody
Anti-Il-10ra antibody
Anti-Cdw210a antibody
Anti-Interleukin-10 Receptor Subunit 1 antibody
Anti-Il-10r Subunit 1 antibody
Anti-Il-10r1 antibody
Anti-Cd Antigen Cd210 antibody
Anti-Il10ra antibody
Anti-Il10r antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance