![Anti-CD21 antibody [B-ly4] {FITC} (STJA0018294)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/187010/412553/STJA0018294_1__86611.1747839607.png?c=1 "Anti-CD21 antibody [B-ly4] {FITC} (STJA0018294)")
![Anti-CD21 antibody [B-ly4] {FITC} (STJA0018294)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/187010/412553/STJA0018294_1__86611.1747839607.png?c=1 "Anti-CD21 antibody [B-ly4] {FITC} (STJA0018294)")
| Short Description : | Mouse monoclonal anti-Complement Receptor Type 2 for use in FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | FC |
| Host: | Mouse |
| Reactivity: | Human |
| Note: | FOR RESEARCH USE ONLY (RUO). |
| Clonality : | Monoclonal |
| Clone ID : | B-ly4 |
| Isotype: | IgG1 |
| Conjugation: | FITC |
| Purification: | Protein A purification |
| Dilution Range: | Please carry out application specific titration to determine the most appropriate dilution ratio. |
| Formulation: | PBS with 0.2% BSA, and 0.09% Sodium Azide |
| Storage Instruction: | Shipped on gel ice packs. Store at 2-8C on arrival. |
| Function | Serves as a receptor for various ligands including complement component CD3d, HNRNPU OR IFNA1. When C3d is bound to antigens, attaches to C3d on B-cell surface and thereby facilitates the recognition and uptake of antigens by B-cells. This interaction enhances B-cell activation and subsequent immune responses. Forms a complex with several partners on the surface of B-cells including CD19, FCRL5 and CD81, to form the B-cell coreceptor complex that plays a crucial role in B-cell activation and signaling. Also induces specific intracellular signaling separately from the BCR and CD19 by activating the tyrosine kinase SRC, which then phosphorylates nucleolin/NCL and triggers AKT and GSK3 kinase activities in a SYK/CD19-independent manner. Acts as a ligand for CD23 (FcepsilonRII), a low-affinity receptor for IgE, which is expressed on B-cells and other immune cells, and thus participates in the regulation of IgE production. (Microbial infection) Acts as a receptor for Epstein-Barr virus. |
| Protein Name | Complement Receptor Type 2Cr2Complement C3d ReceptorEpstein-Barr Virus ReceptorEbv ReceptorCd Antigen Cd21 |
| Database Links | Reactome: R-HSA-977606 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Complement Receptor Type 2 antibodyAnti-Cr2 antibodyAnti-Complement C3d Receptor antibodyAnti-Epstein-Barr Virus Receptor antibodyAnti-Ebv Receptor antibodyAnti-Cd Antigen Cd21 antibodyAnti-CR2 antibodyAnti-C3DR antibody |
Information sourced from Uniprot.org
