Anti-CD194/CCR4 antibody [L291H4] {PE} (STJA0016652)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationPE
IsotypeIgG1k
General Information
| Short Description | Mouse monoclonal anti-C-C Chemokine Receptor Type 4 for use in FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Mouse |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | L291H4 |
| Isotype | IgG1k |
| Conjugation | PE |
| Concentration | 5 Mu L/Test |
| Purification | Affinity purified |
| Formulation | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Storage Instruction | This product can be stored at 2-8Β°C for 12 months. Do not freeze. |
Target Information
| Gene Symbol | CCR4 |
| Gene ID | 1233 |
| Uniprot ID | CCR4_HUMAN |
Additional Info
| Tissue Specificity | Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets.at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells. |
| Post Translational Modifications | In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2. |
| Function | High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. |
| Protein Name | C-C Chemokine Receptor Type 4C-C Ckr-4Cc-Ckr-4Ccr-4Ccr4K5-5Cd Antigen Cd194 |
| Database Links | Reactome: R-HSA-380108Reactome: R-HSA-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-C-C Chemokine Receptor Type 4 antibodyAnti-C-C Ckr-4 antibodyAnti-Cc-Ckr-4 antibodyAnti-Ccr-4 antibodyAnti-Ccr4 antibodyAnti-K5-5 antibodyAnti-Cd Antigen Cd194 antibodyAnti-CCR4 antibodyAnti-CMKBR4 antibody |
Information sourced from Uniprot.org