![Anti-CD18/ITGB2 antibody [TS1/18.1.2.11] {PE/Cyanine5.5} (STJA0001466)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/147250/292739/STJA0001466_1__28758.1631206666.jpg?c=1 "Anti-CD18/ITGB2 antibody [TS1/18.1.2.11] {PE/Cyanine5.5} (STJA0001466)")
![Anti-CD18/ITGB2 antibody [TS1/18.1.2.11] {PE/Cyanine5.5} (STJA0001466)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/147250/292739/STJA0001466_1__28758.1631206666.jpg?c=1 "Anti-CD18/ITGB2 antibody [TS1/18.1.2.11] {PE/Cyanine5.5} (STJA0001466)")
Anti-CD18/ITGB2 antibody [TS1/18.1.2.11] {PE/Cyanine5.5} (STJA0001466)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationPE/Cyanine5.5
IsotypeIgG1k
General Information
| Short Description | Mouse monoclonal anti-Integrin beta-2 for use in FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Mouse |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | TS1/18.1.2.11 |
| Isotype | IgG1k |
| Conjugation | PE/Cyanine5.5 |
| Concentration | 5 Mu L/Test |
| Formulation | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Storage Instruction | Store between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
Target Information
| Gene Symbol | ITGB2 |
| Gene ID | 3689 |
| Uniprot ID | ITB2_HUMAN |
Additional Info
| Tissue Specificity | Leukocytes. Expressed in neutrophils (at protein level). |
| Post Translational Modifications | Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins. |
| Function | Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15.the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. |
| Protein Name | Integrin Beta-2Cell Surface Adhesion Glycoproteins Lfa-1/Cr3/P150 -95 Subunit BetaComplement Receptor C3 Subunit BetaCd Antigen Cd18 |
| Database Links | Reactome: R-HSA-166016Reactome: R-HSA-198933Reactome: R-HSA-202733Reactome: R-HSA-216083Reactome: R-HSA-6785807Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembrane Raft |
| Alternative Antibody Names | Anti-Integrin Beta-2 antibodyAnti-Cell Surface Adhesion Glycoproteins Lfa-1/Cr3/P150 -95 Subunit Beta antibodyAnti-Complement Receptor C3 Subunit Beta antibodyAnti-Cd Antigen Cd18 antibodyAnti-ITGB2 antibodyAnti-CD18 antibodyAnti-MFI7 antibody |
Information sourced from Uniprot.org