Anti-CD161/KLRB1/NK1.1 antibody [KM12.4.7] {APC} (STJA0029544)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationAPC
IsotypeIgG1k
General Information
| Short Description | Mouse monoclonal Killer Cell Lectin-Like Receptor Subfamily B Member 1 antibody for use in FC in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | KM12.4.7 |
| Isotype | IgG1k |
| Conjugation | APC |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Formulation | PBS pH 7.4, 50% glycerol, 0.05% proclin300 |
| Storage Instruction | Store at 4°C for 12 months. Protect from light. Do not freeze. |
Target Information
| Gene Symbol | KLRB1 |
| Gene ID | 3820 |
| Uniprot ID | KLRB1_HUMAN |
Additional Info
| Post Translational Modifications | N-glycosylated. Contains sialic acid residues. |
| Function | Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Also binds to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. |
| Protein Name | Killer Cell Lectin-Like Receptor Subfamily B Member 1C-Type Lectin Domain Family 5 Member BHnkr-P1aNkr-P1aNatural Killer Cell Surface Protein P1aCd Antigen Cd161 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Killer Cell Lectin-Like Receptor Subfamily B Member 1 antibodyAnti-C-Type Lectin Domain Family 5 Member B antibodyAnti-Hnkr-P1a antibodyAnti-Nkr-P1a antibodyAnti-Natural Killer Cell Surface Protein P1a antibodyAnti-Cd Antigen Cd161 antibodyAnti-KLRB1 antibodyAnti-CLEC5B antibodyAnti-NKRP1A antibody |
Information sourced from Uniprot.org