Anti-CD16 antibody [Q32] (STJ96992)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenSynthetic Peptide of CD16
General Information
| Short Description | Mouse monoclonal anti-Low affinity immunoglobulin gamma Fc region receptor III-A and Low affinity immunoglobulin gamma Fc region receptor III-B for use in WB, IHC and IF in Human samples. Datasheet included with dilution recommendations, and related |
| Applications | WB/IHC/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | Q32 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range | WB 1:1000IHC 1:50-300IF 1:50-200 |
| Formulation | Liquid in PBS pH7.4, 0.5% BSA, 0.02% Sodium Azide and 50% Glycerol. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FCGR3BFCGR3A |
| Gene ID | 22152214 |
| Uniprot ID | FCG3B_HUMANFCG3A_HUMAN |
| Immunogen | Synthetic Peptide of CD16 |
| Specificity | The antibody detects endogenous CD16 protein. |
Additional Info
| Post Translational Modifications | Glycosylated. Contains high mannose- and complex-type oligosaccharides. Glycosylation at Asn-180 is mandatory for high affinity binding to the Fc and for discrimination between fucosylated and afucosylated IgG glycoforms. The soluble form is produced by a proteolytic cleavage. |
| Function | Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. |
| Protein Name | Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-ACd16a AntigenFc-Gamma Riii-AlphaFc-Gamma RiiiFc-Gamma RiiiaFcriiiFcriiiaFcr-10Igg Fc Receptor Iii-2Cd Antigen Cd16a |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-2029481Reactome: R-HSA-2029482Reactome: R-HSA-2029485Reactome: R-HSA-9664323Reactome: R-HSA-9664422 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinSecretedExists Also As A Soluble Receptor |
| Alternative Antibody Names | Anti-Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-A antibodyAnti-Cd16a Antigen antibodyAnti-Fc-Gamma Riii-Alpha antibodyAnti-Fc-Gamma Riii antibodyAnti-Fc-Gamma Riiia antibodyAnti-Fcriii antibodyAnti-Fcriiia antibodyAnti-Fcr-10 antibodyAnti-Igg Fc Receptor Iii-2 antibodyAnti-Cd Antigen Cd16a antibodyAnti-FCGR3A antibodyAnti-CD16A antibodyAnti-FCG3 antibodyAnti-FCGR3 antibodyAnti-IGFR3 antibody |
Information sourced from Uniprot.org