| Host: |
Mouse |
| Applications: |
WB/IP/ICC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-CD155/PVR (Extracellular region) is suitable for use in Western Blot, Immunoprecipitation and Immunocytochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
M048 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1 |
| Formulation: |
PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| Purification: |
Protein G Purified |
| Dilution Range: |
WB 1:1000IHCICC 1:100IP 1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PVR |
| Gene ID: |
5817 |
| Uniprot ID: |
PVR_HUMAN |
| Immunogen Region: |
Extracellular region |
| Specificity: |
Clone M048 mouse monoclonal antibody detects a 75 kDa* protein on SDS-PAGE Native" or denatured immunoblots of human A549, NCI-H466, NCI-H1299, MDA-MB-231 and A431 carcinomas. The antibody detects CD155 in the membranes and cytoplasm in NCI-H446 cell |
| Immunogen: |
Clone (M048) was generated from a recombinant protein that included the extracellular region of human CD155 protein. |
| Post Translational Modifications | N-glycosylated. N-glycan at Asn-120: Hex5HexNAc4. Phosphorylated by Src kinases on tyrosine residues in the ITIM motif upon ligation. Interaction with TIGIT is required for Phosphorylation. |
| Function | Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytotoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. (Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport. (Microbial infection) Acts as a receptor for Pseudorabies virus. (Microbial infection) Is prevented to reach cell surface upon infection by Human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells. |
| Protein Name | Poliovirus ReceptorNectin-Like Protein 5Necl-5Cd Antigen Cd155 |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-420597 |
| Cellular Localisation | Isoform Alpha: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform Delta: Cell MembraneIsoform Beta: SecretedIsoform Gamma: Secreted |
| Alternative Antibody Names | Anti-Poliovirus Receptor antibodyAnti-Nectin-Like Protein 5 antibodyAnti-Necl-5 antibodyAnti-Cd Antigen Cd155 antibodyAnti-PVR antibodyAnti-PVS antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
