Anti-CD147 antibody (Extracellular region) [M052] (STJA0005332)

SKU:
STJA0005332-100

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Host: Mouse
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-CD147/Emmprin/Basigin (Extracellular region) is suitable for use in Western Blot research applications.
Clonality: Monoclonal
Clone ID: M052
Conjugation: Unconjugated
Isotype: IgG1
Formulation: PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Purification: Protein G Purified
Dilution Range: WB 1:2000
IHC
ICC
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: BSG
Gene ID: 682
Uniprot ID: BASI_HUMAN
Immunogen Region: Extracellular region
Specificity: Clone M052 mouse monoclonal antibody detects a 38-58 kDa* protein on SDS-PAGE immunoblots of human SK-MES1, MDA-MB-231, MeWo, A431, LNCaP, and NCI-H1915 cells, as well as human brain tissues. The antibody works for western blot and ELISA detection of
Immunogen: Clone (M052) was generated from a proprietary antigen related to the native human CD147 expressed in NCI-H1915 lung cancer cell line.
Tissue Specificity Isoform 1: Retina-specific. Expressed in retinal cone photoreceptors (at protein level). Isoform 2: Expressed in erythrocytes (at protein level). Highly expressed in melanoma cell lines (at protein level). Highly expressed in the heart, kidney, skeletal muscle and testis. Isoform 3: Highly expressed in the bone marrow, fetal liver, lung, testis and thymus. Isoform 4: Highly expressed in the bone marrow, fetal liver, lung, testis and thymus.
Post Translational Modifications Isoform 2: N-glycosylated. Isoform 3: N-glycosylated. Isoform 4: N-glycosylated.
Function Isoform 1: Essential for normal retinal maturation and development. Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors. In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors. May act as a potent stimulator of IL6 secretion in multiple cell lines that include monocytes. Isoform 1: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7 and Dd2. Isoform 2: Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells. Plays an important role in targeting monocarboxylate transporters SLC16A1/GLUT1, SLC16A11 and SLC16A12 to the plasma membrane. Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling. Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA (isoform VEGF-165 and VEGF-121) and KDR/VEGFR2 in endothelial cells. Plays a key role in regulating tumor growth, invasion, metastasis and neoangiogenesis by stimulating the production and release of extracellular matrix metalloproteinases and KDR/VEGFR2 by both tumor cells and stromal cells (fibroblasts and endothelial cells). Isoform 2: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7, Dd2, 7G8 and HB3. Binding of P.falciparum RH5 results in BSG dimerization which triggers an increase in intracellular Ca(2+) in the erythrocyte. This essential step leads to a rearrangement of the erythrocyte cytoskeleton required for the merozoite invasion. Isoform 2: (Microbial infection) Can facilitate human SARS coronavirus (SARS-CoV-1) infection via its interaction with virus-associated PPIA/CYPA. Isoform 2: (Microbial infection) Can facilitate HIV-1 infection via its interaction with virus-associated PPIA/CYPA. Isoform 2: (Microbial infection) First described as a receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is not required for SARS-CoV-2 infection. Isoform 2: (Microbial infection) Acts as a receptor for measles virus. Isoform 2: (Microbial infection) Promotes entry of pentamer-expressing human cytomegalovirus (HCMV) into epithelial and endothelial cells.
Protein Name Basigin
5f7
Collagenase Stimulatory Factor
Extracellular Matrix Metalloproteinase Inducer
Emmprin
Hepatoma-Associated Antigen
Hab18g
Leukocyte Activation Antigen M6
Ok Blood Group Antigen
Tumor Cell-Derived Collagenase Stimulatory Factor
Tcsf
Cd Antigen Cd147
Database Links Reactome: R-HSA-1474228
Reactome: R-HSA-210991
Reactome: R-HSA-216083
Reactome: R-HSA-433692
Reactome: R-HSA-5619070
Reactome: R-HSA-70268
Reactome: R-HSA-9749641
Cellular Localisation Melanosome
Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv
Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Photoreceptor Inner Segment
Cell Projection
Cilium
Photoreceptor Outer Segment
Isoform 2: Cell Membrane
Endosome
Endoplasmic Reticulum Membrane
Basolateral Cell Membrane
Isoform 3: Cell Membrane
Isoform 4: Cell Membrane
Alternative Antibody Names Anti-Basigin antibody
Anti-5f7 antibody
Anti-Collagenase Stimulatory Factor antibody
Anti-Extracellular Matrix Metalloproteinase Inducer antibody
Anti-Emmprin antibody
Anti-Hepatoma-Associated Antigen antibody
Anti-Hab18g antibody
Anti-Leukocyte Activation Antigen M6 antibody
Anti-Ok Blood Group Antigen antibody
Anti-Tumor Cell-Derived Collagenase Stimulatory Factor antibody
Anti-Tcsf antibody
Anti-Cd Antigen Cd147 antibody
Anti-BSG antibody
Anti-UNQ6505 antibody
Anti-PRO21383 antibody

Information sourced from Uniprot.org

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