Anti-CD146/MCAM antibody [Fs0349] (STJA0032121)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
General Information
| Short Description | Mouse monoclonal anti-CD146/MCAM for use in ELISA, FCM, ICC and IF in Human, Mouse, Rabbit and Canine samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/FCM/ICC/IF |
| Host | Mouse |
| Reactivity | Human/Mouse/Rabbit/Canine |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | Fs0349 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
| Endotoxin | Please contact us for this information. |
Target Information
| Gene Symbol | MCAM |
| Gene ID | 4162 |
| Uniprot ID | MUC18_HUMAN |
Additional Info
| Function | Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. |
| Protein Name | Cell Surface Glycoprotein Muc18Cell Surface Glycoprotein P1h12Melanoma Cell Adhesion MoleculeMelanoma-Associated Antigen A32Melanoma-Associated Antigen Muc18S-Endo 1 Endothelial-Associated AntigenCd Antigen Cd146 |
| Database Links | Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013405Reactome: R-HSA-9013408Reactome: R-HSA-9013423Reactome: R-HSA-9035034 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Cell Surface Glycoprotein Muc18 antibodyAnti-Cell Surface Glycoprotein P1h12 antibodyAnti-Melanoma Cell Adhesion Molecule antibodyAnti-Melanoma-Associated Antigen A32 antibodyAnti-Melanoma-Associated Antigen Muc18 antibodyAnti-S-Endo 1 Endothelial-Associated Antigen antibodyAnti-Cd Antigen Cd146 antibodyAnti-MCAM antibodyAnti-MUC18 antibody |
Information sourced from Uniprot.org