Anti-CD14 antibody (STJA0010228)

SKU:
STJA0010228

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Monocyte differentiation antigen CD14 is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:1000-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CD14
Gene ID: 929
Uniprot ID: CD14_HUMAN
Specificity: This antibody detects endogenous levels of Human CD14
Immunogen: Synthesized peptide derived from human CD14
Tissue Specificity Detected on macrophages (at protein level). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes.also expressed by most tissue macrophages.
Post Translational Modifications N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
Function Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).
Protein Name Monocyte Differentiation Antigen Cd14
Myeloid Cell-Specific Leucine-Rich Glycoprotein
Cd Antigen Cd14 Cleaved Into - Monocyte Differentiation Antigen Cd14 - Urinary Form - Monocyte Differentiation Antigen Cd14 - Membrane-Bound Form
Database Links Reactome: R-HSA-1236974
Reactome: R-HSA-140534
Reactome: R-HSA-166016
Reactome: R-HSA-166020
Reactome: R-HSA-166058
Reactome: R-HSA-166166
Reactome: R-HSA-168179
Reactome: R-HSA-168188
Reactome: R-HSA-2562578
Reactome: R-HSA-5602498
Reactome: R-HSA-5603041
Reactome: R-HSA-5686938
Reactome: R-HSA-6798695
Reactome: R-HSA-936964
Reactome: R-HSA-937041
Reactome: R-HSA-937072
Reactome: R-HSA-975163
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Secreted
Membrane Raft
Golgi Apparatus
Secreted Forms May Arise By Cleavage Of The Gpi Anchor
Alternative Antibody Names Anti-Monocyte Differentiation Antigen Cd14 antibody
Anti-Myeloid Cell-Specific Leucine-Rich Glycoprotein antibody
Anti-Cd Antigen Cd14 Cleaved Into - Monocyte Differentiation Antigen Cd14 - Urinary Form - Monocyte Differentiation Antigen Cd14 - Membrane-Bound Form antibody
Anti-CD14 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance