Anti-CD14 antibody [MEM-15] (STJ16100038)

SKU:
STJ16100038-01

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Host: Mouse
Applications: FC/IP
Reactivity: Non-Human Primates/Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-CD14/human monocyte is suitable for use in Flow Cytometry and Immunoprecipitation research applications.
Clonality: Monoclonal
Clone ID: MEM-15
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Concentration: 1 mg/mL
Dilution Range: FC 4 µg/ml-IP to be determined
Storage Instruction: Store at 2-8°C upon receipt.
Gene Symbol: CD14
Gene ID: 929
Uniprot ID: CD14_HUMAN
Immunogen: A crude mixture of human urinary proteins precipitated by ammonium sulphate from the urine of a patient suffering from proteinuria.
Tissue Specificity Detected on macrophages (at protein level). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes.also expressed by most tissue macrophages.
Post Translational Modifications N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
Function Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).
Protein Name Monocyte Differentiation Antigen Cd14
Myeloid Cell-Specific Leucine-Rich Glycoprotein
Cd Antigen Cd14 Cleaved Into - Monocyte Differentiation Antigen Cd14 - Urinary Form - Monocyte Differentiation Antigen Cd14 - Membrane-Bound Form
Database Links Reactome: R-HSA-1236974
Reactome: R-HSA-140534
Reactome: R-HSA-166016
Reactome: R-HSA-166020
Reactome: R-HSA-166058
Reactome: R-HSA-166166
Reactome: R-HSA-168179
Reactome: R-HSA-168188
Reactome: R-HSA-2562578
Reactome: R-HSA-5602498
Reactome: R-HSA-5603041
Reactome: R-HSA-5686938
Reactome: R-HSA-6798695
Reactome: R-HSA-936964
Reactome: R-HSA-937041
Reactome: R-HSA-937072
Reactome: R-HSA-975163
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Secreted
Membrane Raft
Golgi Apparatus
Secreted Forms May Arise By Cleavage Of The Gpi Anchor
Alternative Antibody Names Anti-Monocyte Differentiation Antigen Cd14 antibody
Anti-Myeloid Cell-Specific Leucine-Rich Glycoprotein antibody
Anti-Cd Antigen Cd14 Cleaved Into - Monocyte Differentiation Antigen Cd14 - Urinary Form - Monocyte Differentiation Antigen Cd14 - Membrane-Bound Form antibody
Anti-CD14 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance