Anti-CD131 antibody {PE} (STJ11108813)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationPE
IsotypeIgG
ImmunogenRecombinant protein (or fragment).This information is considered to be commercially sensitive.
General Information
| Short Description | Rabbit monoclonal CD131 antibody for use in FC in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Isotype | IgG |
| Conjugation | PE |
| Purification | Affinity purification |
| Dilution Range | FC, 5 Mu l per 10^6 cells in 100 Mu l volume |
| Formulation | PBS containing 0.2% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis) , pH 7.3. |
| Storage Instruction | Store at 4°C for up to 1 year from the date of receipt. Do not freeze. |
Target Information
| Gene Symbol | CSF2RB |
| Gene ID | 1439 |
| Uniprot ID | IL3RB_HUMAN |
| Immunogen | Recombinant protein (or fragment).This information is considered to be commercially sensitive. |
Additional Info
| Post Translational Modifications | May be phosphorylated by LYN. |
| Function | Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA. In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway. |
| Protein Name | Cytokine Receptor Common Subunit BetaCdw131Gm-Csf/Il-3/Il-5 Receptor Common Beta SubunitCd Antigen Cd131 |
| Database Links | Reactome: R-HSA-512988Reactome: R-HSA-5673001Reactome: R-HSA-5683826Reactome: R-HSA-5688849Reactome: R-HSA-5688890Reactome: R-HSA-912526 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Cytokine Receptor Common Subunit Beta antibodyAnti-Cdw131 antibodyAnti-Gm-Csf/Il-3/Il-5 Receptor Common Beta Subunit antibodyAnti-Cd Antigen Cd131 antibodyAnti-CSF2RB antibodyAnti-IL3RB antibodyAnti-IL5RB antibody |
Information sourced from Uniprot.org