Anti-CD13/ANPEP antibody (Internal) (STJ73436)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-CD13/ANPEP (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 150kDa band observed in Human Kidney lysates (calculated MW of 110kDa according to NP_001141.2). The observed molecular weight corresponds to the glycosylated form. Recommended |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | ANPEP |
| Gene ID | 290 |
| Uniprot ID | AMPN_HUMAN |
| Accession Number | NP_001141.2 |
| Immunogen Region | Internal |
| Immunogen Sequence | QLEQFKKDNEET |
Additional Info
| Post Translational Modifications | Sulfated. N- and O-glycosylated. May undergo proteolysis and give rise to a soluble form. |
| Function | Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity. (Microbial infection) Acts as a receptor for human coronavirus 229E/HCoV-229E. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. (Microbial infection) Mediates as well Human cytomegalovirus (HCMV) infection. |
| Protein Name | Aminopeptidase NAp-NHapnAlanyl AminopeptidaseAminopeptidase MAp-MMicrosomal AminopeptidaseMyeloid Plasma Membrane Glycoprotein Cd13Gp150Cd Antigen Cd13 |
| Database Links | Reactome: R-HSA-2022377Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinAlso Found As A Soluble Form |
| Alternative Antibody Names | Anti-Aminopeptidase N antibodyAnti-Ap-N antibodyAnti-Hapn antibodyAnti-Alanyl Aminopeptidase antibodyAnti-Aminopeptidase M antibodyAnti-Ap-M antibodyAnti-Microsomal Aminopeptidase antibodyAnti-Myeloid Plasma Membrane Glycoprotein Cd13 antibodyAnti-Gp150 antibodyAnti-Cd Antigen Cd13 antibodyAnti-ANPEP antibodyAnti-APN antibodyAnti-CD13 antibodyAnti-PEPN antibody |
Information sourced from Uniprot.org