![Anti-CD124/IL4R/IL-4R Alpha nanobody [SAA1420] (STJN000528)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/201141/413240/STJN000528-SDS-PAGE-1__72088.1749232728.jpg?c=1 "Anti-CD124/IL4R/IL-4R Alpha nanobody [SAA1420] (STJN000528)")
![Anti-CD124/IL4R/IL-4R Alpha nanobody [SAA1420] (STJN000528)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/201141/413240/STJN000528-SDS-PAGE-1__72088.1749232728.jpg?c=1 "Anti-CD124/IL4R/IL-4R Alpha nanobody [SAA1420] (STJN000528)")
Anti-CD124/IL4R/IL-4R Alpha nanobody [SAA1420] (STJN000528)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Interleukin-4 Receptor Subunit Alpha is suitable for use in ELISA research applications. |
| Applications | ELISA |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1420 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | IL4R |
| Gene ID | 3566 |
| Uniprot ID | IL4RA_HUMAN |
Additional Info
| Post Translational Modifications | On IL4 binding, phosphorylated on C-terminal tyrosine residues. Phosphorylation on any one of tyrosine residues, Tyr-575, Tyr-603 or Tyr-631, is required for STAT6-induced gene induction. The soluble form (sIL4R/IL4BP) can also be produced by proteolytic cleavage at the cell surface (shedding) by a metalloproteinase. |
| Function | Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells. |
| Protein Name | Interleukin-4 Receptor Subunit AlphaIl-4 Receptor Subunit AlphaIl-4r Subunit AlphaIl-4r-AlphaIl-4raCd Antigen Cd124 Cleaved Into - Soluble Interleukin-4 Receptor Subunit AlphaSoluble Il-4 Receptor Subunit AlphaSoluble Il-4r-AlphaSil4ralpha/ProtIl-4-Binding ProteinIl4-Bp |
| Database Links | Reactome: R-HSA-6785807 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Secreted |
| Alternative Nanobody Names | Anti-Interleukin-4 Receptor Subunit Alpha nanobodyAnti-Il-4 Receptor Subunit Alpha nanobodyAnti-Il-4r Subunit Alpha nanobodyAnti-Il-4r-Alpha nanobodyAnti-Il-4ra nanobodyAnti-Cd Antigen Cd124 Cleaved Into - Soluble Interleukin-4 Receptor Subunit Alpha nanobodyAnti-Soluble Il-4 Receptor Subunit Alpha nanobodyAnti-Soluble Il-4r-Alpha nanobodyAnti-Sil4ralpha/Prot nanobodyAnti-Il-4-Binding Protein nanobodyAnti-Il4-Bp nanobodyAnti-IL4R nanobodyAnti-IL4RA nanobodyAnti-582J2.1 nanobody |
Information sourced from Uniprot.org