Anti-CD124/IL4R antibody [Fs0362] (STJA0032148)
SPECIFICATIONS
ClonalityMonoclonal
HostRat
ConjugationUnconjugated
IsotypeIgG1
General Information
| Short Description | Rat monoclonal anti-CD124/IL4R for use in ELISA, FCM and Neut in Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/FCM/Neut |
| Host | Rat |
| Reactivity | Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | Fs0362 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
| Endotoxin | Please contact us for this information. |
Target Information
| Gene Symbol | Il4r |
| Gene ID | 25084 |
| Uniprot ID | IL4RA_RAT |
Additional Info
| Post Translational Modifications | On IL4 binding, phosphorylated on C-terminal tyrosine residues. |
| Function | Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. Isoform 2 (soluble form) inhibits IL4-induced spleen cell proliferation. |
| Protein Name | Interleukin-4 Receptor Subunit AlphaIl-4 Receptor Subunit AlphaIl-4r Subunit AlphaIl-4r-AlphaIl-4raCd Antigen Cd124 |
| Database Links | Reactome: R-RNO-6785807 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Secreted |
| Alternative Antibody Names | Anti-Interleukin-4 Receptor Subunit Alpha antibodyAnti-Il-4 Receptor Subunit Alpha antibodyAnti-Il-4r Subunit Alpha antibodyAnti-Il-4r-Alpha antibodyAnti-Il-4ra antibodyAnti-Cd Antigen Cd124 antibodyAnti-Il4r antibodyAnti-Il4ra antibody |
Information sourced from Uniprot.org