![Anti-CD123/IL3RA nanobody [SAA1297] (STJN000182)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200795/412977/STJN000182-SDS-PAGE-1__85047.1749232502.jpg?c=1 "Anti-CD123/IL3RA nanobody [SAA1297] (STJN000182)")
![Anti-CD123/IL3RA nanobody [SAA1297] (STJN000182)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200795/412977/STJN000182-SDS-PAGE-1__85047.1749232502.jpg?c=1 "Anti-CD123/IL3RA nanobody [SAA1297] (STJN000182)")
Anti-CD123/IL3RA nanobody [SAA1297] (STJN000182)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Interleukin-3 Receptor Subunit Alpha is suitable for use in ELISA, Flow Cytometry and SPR research applications. |
| Applications | ELISA/FC/SPR |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1297 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | IL3RA |
| Gene ID | 3563 |
| Uniprot ID | IL3RA_HUMAN |
Additional Info
| Function | Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program. |
| Protein Name | Interleukin-3 Receptor Subunit AlphaIl-3 Receptor Subunit AlphaIl-3r Subunit AlphaIl-3r-AlphaIl-3raCd Antigen Cd123 |
| Database Links | Reactome: R-HSA-512988Reactome: R-HSA-5673001Reactome: R-HSA-912526 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Nanobody Names | Anti-Interleukin-3 Receptor Subunit Alpha nanobodyAnti-Il-3 Receptor Subunit Alpha nanobodyAnti-Il-3r Subunit Alpha nanobodyAnti-Il-3r-Alpha nanobodyAnti-Il-3ra nanobodyAnti-Cd Antigen Cd123 nanobodyAnti-IL3RA nanobodyAnti-IL3R nanobody |
Information sourced from Uniprot.org