![Anti-CD120a/TNFRSF1A/TNFR1 nanobody [Clone: 70] (STJN000592)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/201205/413303/STJN000592-SDS-PAGE-1__70925.1749232779.jpg?c=1 "Anti-CD120a/TNFRSF1A/TNFR1 nanobody [Clone: 70] (STJN000592)")
![Anti-CD120a/TNFRSF1A/TNFR1 nanobody [Clone: 70] (STJN000592)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/201205/413303/STJN000592-SDS-PAGE-1__70925.1749232779.jpg?c=1 "Anti-CD120a/TNFRSF1A/TNFR1 nanobody [Clone: 70] (STJN000592)")
Anti-CD120a/TNFRSF1A/TNFR1 nanobody [Clone: 70] (STJN000592)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Tumor Necrosis Factor Receptor Superfamily Member 1a is suitable for use in ELISA and FuncS research applications. |
| Applications | ELISA/FuncS |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | Clone: 70 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | TNFRSF1A |
| Gene ID | 7132 |
| Uniprot ID | TNR1A_HUMAN |
Additional Info
| Function | Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 1aTumor Necrosis Factor Receptor 1Tnf-R1Tumor Necrosis Factor Receptor Type ITnf-RiTnfr-IP55P60Cd Antigen Cd120a Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1a - Membrane Form - Tumor Necrosis Factor-Binding Protein 1Tbpi |
| Database Links | Reactome: R-HSA-5357786Reactome: R-HSA-5357905Reactome: R-HSA-5357956Reactome: R-HSA-5626978Reactome: R-HSA-5669034Reactome: R-HSA-6783783Reactome: R-HSA-75893 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinGolgi Apparatus MembraneSecretedA Secreted Form Is Produced Through Proteolytic ProcessingIsoform 4: SecretedLacks A Golgi-Retention MotifIs Not Membrane Bound And Therefore Is Secreted |
| Alternative Nanobody Names | Anti-Tumor Necrosis Factor Receptor Superfamily Member 1a nanobodyAnti-Tumor Necrosis Factor Receptor 1 nanobodyAnti-Tnf-R1 nanobodyAnti-Tumor Necrosis Factor Receptor Type I nanobodyAnti-Tnf-Ri nanobodyAnti-Tnfr-I nanobodyAnti-P55 nanobodyAnti-P60 nanobodyAnti-Cd Antigen Cd120a Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1a - Membrane Form - Tumor Necrosis Factor-Binding Protein 1 nanobodyAnti-Tbpi nanobodyAnti-TNFRSF1A nanobodyAnti-TNFAR nanobodyAnti-TNFR1 nanobody |
Information sourced from Uniprot.org