Anti-CD120a/TNFRSF1A antibody [H398] {FITC} (STJA0028291)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationFITC
IsotypeIgG2ak
General Information
| Short Description | Mouse monoclonal Tumor Necrosis Factor Receptor Superfamily Member 1a antibody for use in FC in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | H398 |
| Isotype | IgG2ak |
| Conjugation | FITC |
| Concentration | 05 mg/mL |
| Purification | Purified |
| Formulation | PBS pH 7.4, 50% glycerol, 0.05% proclin300 |
| Storage Instruction | Store at 4°C for 12 months Protect from light Do not freeze |
Target Information
| Gene Symbol | TNFRSF1A |
| Gene ID | 7132 |
| Uniprot ID | TNR1A_HUMAN |
Additional Info
| Function | Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 1aTumor Necrosis Factor Receptor 1Tnf-R1Tumor Necrosis Factor Receptor Type ITnf-RiTnfr-IP55P60Cd Antigen Cd120a Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1a - Membrane Form - Tumor Necrosis Factor-Binding Protein 1Tbpi |
| Database Links | Reactome: R-HSA-5357786Reactome: R-HSA-5357905Reactome: R-HSA-5357956Reactome: R-HSA-5626978Reactome: R-HSA-5669034Reactome: R-HSA-6783783Reactome: R-HSA-75893 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinGolgi Apparatus MembraneSecretedA Secreted Form Is Produced Through Proteolytic ProcessingIsoform 4: SecretedLacks A Golgi-Retention MotifIs Not Membrane Bound And Therefore Is Secreted |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Receptor Superfamily Member 1a antibodyAnti-Tumor Necrosis Factor Receptor 1 antibodyAnti-Tnf-R1 antibodyAnti-Tumor Necrosis Factor Receptor Type I antibodyAnti-Tnf-Ri antibodyAnti-Tnfr-I antibodyAnti-P55 antibodyAnti-P60 antibodyAnti-Cd Antigen Cd120a Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1a - Membrane Form - Tumor Necrosis Factor-Binding Protein 1 antibodyAnti-Tbpi antibodyAnti-TNFRSF1A antibodyAnti-TNFAR antibodyAnti-TNFR1 antibody |
Information sourced from Uniprot.org