Anti-CD11b antibody [PT0631R] (STJA0039386)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgGk
General Information
| Short Description | Rabbit monoclonal anti-Cyclin-Dependent Kinase 11b for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | PT0631R |
| Isotype | IgGk |
| Conjugation | Unconjugated |
| Purification | Protein A |
| Dilution Range | IHC 1:4000-1:20000WB 1:2000-1:10000IF 1:200-1:1000ELISA 1:5000-1:20000 |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CDK11B |
| Gene ID | 984 |
| Uniprot ID | CD11B_HUMAN |
| Specificity | Endogenous |
Additional Info
| Post Translational Modifications | During FAS- or TNF-induced apoptosis, isoform SV9 is cleaved by caspases to produce p110C, a fragment that contains the C-terminal kinase domain. Phosphorylation at Ser-115 creates a binding site for 14-3-3 proteins. p110C can be autophosphorylated. |
| Function | Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. |
| Protein Name | Cyclin-Dependent Kinase 11bCell Division Cycle 2-Like Protein Kinase 1Clk-1Cell Division Protein Kinase 11bGalactosyltransferase-Associated Protein Kinase P58/GtaPitslre Serine/Threonine-Protein Kinase Cdc2l1P58 Clk-1 |
| Database Links | Reactome: R-HSA-380270 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Cyclin-Dependent Kinase 11b antibodyAnti-Cell Division Cycle 2-Like Protein Kinase 1 antibodyAnti-Clk-1 antibodyAnti-Cell Division Protein Kinase 11b antibodyAnti-Galactosyltransferase-Associated Protein Kinase P58/Gta antibodyAnti-Pitslre Serine/Threonine-Protein Kinase Cdc2l1 antibodyAnti-P58 Clk-1 antibodyAnti-CDK11B antibodyAnti-CDC2L1 antibodyAnti-CDK11 antibodyAnti-PITSLREA antibodyAnti-PK58 antibody |
Information sourced from Uniprot.org